Deciphering the Functional Status of Breast Cancers through the Analysis of Their Extracellular Vesicles.

ABSTRACT: Breast cancer (BC) accounts for the highest incidence of tumor-related mortality among women worldwide, justifying the growing search for molecular tools for the early diagnosis and follow-up of BC patients under treatment. Circulating extracellular vesicles (EVs) are membranous nanocompartments produced by all human cells, including tumor cells. Since minimally invasive methods collect EVs, which represent reservoirs of signals for cell communication, these particles have attracted the interest of many researchers aiming to improve BC screening and treatment. Here, we analyzed the cargoes of BC-derived EVs, both proteins and nucleic acids, which yielded a comprehensive list of potential markers divided into four distinct categories, namely, (i) modulation of aggressiveness and growth; (ii

SUBMITTER: Murillo Carrasco AG 

PROVIDER: S-EPMC10455604 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature