Charting the Path: Navigating Embryonic Development to Potentially Safeguard against Congenital Heart Defects.

ABSTRACT: Congenital heart diseases (CHDs) are structural or functional defects present at birth due to improper heart development. Current therapeutic approaches to treating severe CHDs are primarily palliative surgical interventions during the peri- or prenatal stages, when the heart has fully developed from faulty embryogenesis. However, earlier interventions during embryonic development have the potential for better outcomes, as demonstrated by fetal cardiac interventions performed in utero, which have shown improved neonatal and prenatal survival rates, as well as reduced lifelong morbidity. Extensive research on heart development has identified key steps, cellular players, and the intricate network of signaling pathways and transcription factors governing cardiogenesis. Additionally, some repo

SUBMITTER: Braganca J 

PROVIDER: S-EPMC10455635 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature