First Report of Azole-Resistant Aspergillus fumigatus with TR₄₆/Y121F/T289A Mutations in Kuwait and an Update on Their Occurrence in the Middle East.

ABSTRACT: Pulmonary aspergillosis is a common fungal infection with several clinical manifestations including invasive, allergic and chronic chest diseases. Invasive pulmonary aspergillosis (IPA) is a leading cause of death in immunocompromised patients, particularly those receiving chemotherapy and among bone marrow transplant recipients. Aspergillus fumigatus is the most prevalent causative agent and voriconazole is the first-line therapy for IPA. In this study, we report the first isolation of voriconazole-resistant A. fumigatus carrying TR₄₆/Y121F/T289A mutations from an immunocompromised pregnant lady in Kuwait. The patient was successfully treated for a probable respiratory infection with caspofungin and voriconazole. The literature review from PubMed has identified it

SUBMITTER: Asadzadeh M 

PROVIDER: S-EPMC10455753 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature