Autophagy in Heart Failure: Insights into Mechanisms and Therapeutic Implications.

ABSTRACT: Autophagy, a dynamic and complex process responsible for the clearance of damaged cellular components, plays a crucial role in maintaining myocardial homeostasis. In the context of heart failure, autophagy has been recognized as a response mechanism aimed at counteracting pathogenic processes and promoting cellular health. Its relevance has been underscored not only in various animal models, but also in the human heart. Extensive research efforts have been dedicated to understanding the significance of autophagy and unravelling its complex molecular mechanisms. This review aims to consolidate the current knowledge of the involvement of autophagy during the progression of heart failure. Specifically, we provide a comprehensive overview of published data on the impact of autophagy deregulati

SUBMITTER: Bielawska M 

PROVIDER: S-EPMC10456056 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature