GABA_B Receptors Tonically Inhibit Motoneurons and Neurotransmitter Release from Descending and Primary Afferent Fibers.

ABSTRACT: Motoneurons receive thousands of excitatory and inhibitory synapses from descending tracts and primary afferent fibers. The excitability of these neurons must be precisely regulated to respond adequately to the requirements of the environment. In this context, GABA_A and GABA_B receptors regulate motoneuron synaptic strength. GABA_A and GABA_B receptors are expressed on primary afferent fibers and motoneurons, while in the descending afferent fibers, only the GABA_B receptors are expressed. However, it remains to be known where the GABA that activates them comes from since the GABAergic interneurons that make axo-axonic contacts with primary afferents have yet to be identified in the descending afferent terminals. Thus, the main aim of the

SUBMITTER: Delgado-Ramirez X 

PROVIDER: S-EPMC10456076 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature