Drug Delivery through Epidermal Tissue Cells by Functionalized Biosilica from Diatom Microalgae.

ABSTRACT: Diatom microalgae are a natural source of fossil biosilica shells, namely the diatomaceous earth (DE), abundantly available at low cost. High surface area, mesoporosity and biocompatibility, as well as the availability of a variety of approaches for surface chemical modification, make DE highly profitable as a nanostructured material for drug delivery applications. Despite this, the studies reported so far in the literature are generally limited to the development of biohybrid systems for drug delivery by oral or parenteral administration. Here we demonstrate the suitability of diatomaceous earth properly functionalized on the surface with n-octyl chains as an efficient system for local drug delivery to skin tissues. Naproxen was selected as a non-steroidal anti-inflammatory model d

SUBMITTER: Vona D 

PROVIDER: S-EPMC10456091 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature