Epidemiology, Diagnostic Strategies, and Therapeutic Advances in Diffuse Midline Glioma.

ABSTRACT: Object: Diffuse midline glioma (DMG) is a highly aggressive and lethal brain tumor predominantly affecting children and young adults. Previously known as diffuse intrinsic pontine glioma (DIPG) or grade IV brain stem glioma, DMG has recently been reclassified as "diffuse midline glioma" according to the WHO CNS5 nomenclature, expanding the DMG demographic. Limited therapeutic options result in a poor prognosis, despite advances in diagnosis and treatment. Radiotherapy has historically been the primary treatment modality to improve patient survival. Methods: This systematic literature review aims to comprehensively compile information on the diagnosis and treatment of DMG from 1 January 2012 to 31 July 2023. The review followed the PRISMA (Preferred Reporting Items for Systema

SUBMITTER: Miguel Llordes G 

PROVIDER: S-EPMC10456112 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature