Comparative analysis of multiorgan toxicity induced by long term use of disease modifying anti-rheumatic drugs.

ABSTRACT: The constant use of disease modifying anti rheumatic drugs affects the functioning of multiple organs inside the body. Some drugs are more toxic than others. The present case control investigation was designed to evaluate the comparative toxicity of methotrexate and leflunomide on multiple organs in rheumatoid arthritis patients. For this purpose, 100 subjects with confirmed rheumatoid arthritis condition were recruited form tertiary care center. Whereas 50 age matched controls were recruited from the local healthy population. Participants of the study were categorized into three groups with equal numbers of subjects in each group (n = 50). Group 1 comprised rheumatoid arthritis patients on methotrexate treatment, group 2 included rheumatoid arthritis patients on leflunomide treatment and

SUBMITTER: Mumtaz T 

PROVIDER: S-EPMC10456141 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature