Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis.

ABSTRACT:

Background

Urolithiasis is a common urological disease with increasing incidence worldwide, and preventing its risk poses significant challenges. Here, we used Mendelian randomization (MR) framework to genetically assess the causal nature of multifaceted risk factors on urolithiasis.

Methods

17 potential risk factors associated with urolithiasis were collected from recently published observational studies, which can be categorized basically into lifestyle factors and circulating biomarkers. The instrumental variables of risk factors were selected from large-scale genome-wide association studies (N ≤ 607,291). Summary-level data on urolithiasis were obtained from UK Biobank (UKB) (3,625 cases and 459,308 noncases) and the FinnGen consortium (5,347 cases and 213,445 noncases).

SUBMITTER: Fang H 

PROVIDER: S-EPMC10456171 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature