Specific Learning Disorders: Variation Analysis of 15 Candidate Genes in 9 Multiplex Families.

ABSTRACT: Background and Objectives: Specific Learning Disorder (SLD) is a complex neurobiological disorder characterized by a persistent difficult in reading (dyslexia), written expression (dysgraphia), and mathematics (dyscalculia). The hereditary and genetic component is one of the underlying causes of SLD, but the relationship between genes and the environment should be considered. Several genetic studies were performed in different populations to identify causative genes. Materials and Methods: Here, we show the analysis of 9 multiplex families with at least 2 individuals diagnosed with SLD per family, with a total of 37 persons, 21 of whom are young subjects with SLD, by means of Next-Generation Sequencing (NGS) to identify possible causative mutations in a panel of 15 candidate

SUBMITTER: Cali F 

PROVIDER: S-EPMC10456226 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature