Radiation Therapy Changed the Second Malignancy Pattern in Rectal Cancer Survivors.

ABSTRACT: Background and Objectives: Radiotherapy (RT) plays an important role in the treatment for locally advanced rectal cancer patients. It can bring radio exposure together with the survival benefit. Cancer survivors are generally at an increased risk for second malignancies, and survivors receiving RT may have higher risks than survivors not receiving RT. Whether the risk of an all-site second malignancy may increase after RT is still debated. This study aims to compare the second malignancy pattern in rectal cancer survivors after RT. Materials and Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used for analysis. In total, 49,961 rectal cancer patients (20-84 years of age) were identified between 2000 and 2012 from 18 SEER registries. All patients u

SUBMITTER: Ye X 

PROVIDER: S-EPMC10456705 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature