Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network.

ABSTRACT: Salient cues, such as the rising sun or availability of food, entrain biological clocks for behavioral adaptation. The mechanisms underlying entrainment to food availability remain elusive. Using single-nucleus RNA sequencing during scheduled feeding, we identified a dorsomedial hypothalamus leptin receptor-expressing (DMH^LepR) neuron population that up-regulates circadian entrainment genes and exhibits calcium activity before an anticipated meal. Exogenous leptin, silencing, or chemogenetic stimulation of DMH^LepR neurons disrupts the development of molecular and behavioral food entrainment. Repetitive DMH^LepR neuron activation leads to the partitioning of a secondary bout of circadian locomotor activity that is in phase with the stimulation and dependent o

SUBMITTER: Tang Q 

PROVIDER: S-EPMC10456850 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature