The Expectation and Reality of the HepG2 Core Metabolic Profile.

ABSTRACT: To represent the composition of small molecules circulating in HepG2 cells and the formation of the "core" of characteristic metabolites that often attract researchers' attention, we conducted a meta-analysis of 56 datasets obtained through metabolomic profiling via mass spectrometry and NMR. We highlighted the 288 most commonly studied compounds of diverse chemical nature and analyzed metabolic processes involving these small molecules. Building a complete map of the metabolome of a cell, which encompasses the diversity of possible impacts on it, is a severe challenge for the scientific community, which is faced not only with natural limitations of experimental technologies, but also with the absence of transparent and widely accepted standards for processing and presenting the obtained m

SUBMITTER: Kiseleva OI 

PROVIDER: S-EPMC10456947 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature