Mechanism of baixiangdan capsules on anti-neuroinflammation: combining dry and wet experiments.

ABSTRACT: Neuroinflammation plays an important role in the pathogenesis of neurological disorders, and despite intensive research, treatment of neuroinflammation remains limited. BaiXiangDan capsule (BXD) is widely used in clinical practice. However, systematic studies on the direct role and mechanisms of BXD in neuroinflammation are still lacking. We systematically evaluated the potential pharmacological mechanisms of BXD on neuroinflammation using network pharmacological analysis combined with experimental validation. Multiple databases are used to mine potential targets for bioactive ingredients, drug targets and neuroinflammation. GO and KEGG pathway analysis was also performed. Interactions between active ingredients and pivotal targets were confirmed by molecular docking. An experimental model

SUBMITTER: Yu Q 

PROVIDER: S-EPMC10457058 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature