Causal pathway from telomere length to occurrence and 28-day mortality of sepsis: an observational and mendelian randomization study.

ABSTRACT:

Background

Telomeres are considered to be a physiological marker of aging. Elucidating relationship between telomere length and sepsis is an essential step towards understanding the biological processes involved in sepsis and its salvation. Mendelian randomization studies based on SNPs have given us new insights into genetic susceptibility to disease.

Objectives

To explore the causal pathway from telomere length to occurrence and 28-day mortality of sepsis.

Methods

Leveraging genetic information resource of UK Biobank, we captured three groups of large-scale GWAS data: leukocyte telomere length (LTL), sepsis and all-cause death of 28-day. Study design consisted of three parts: forward analysis, reverse analysis and one-way analysis. Genetic instrumental variables were

SUBMITTER: Jiang T 

PROVIDER: S-EPMC10457059 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature