Ontology highlight
ABSTRACT:
SUBMITTER: Di Scipio M
PROVIDER: S-EPMC10457310 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Di Scipio Matteo M Khan Mohammad M Mao Shihong S Chong Michael M Judge Conor C Pathan Nazia N Perrot Nicolas N Nelson Walter W Lali Ricky R Di Shuang S Morton Robert R Petch Jeremy J Paré Guillaume G
Nature communications 20230825 1
Identification of gene-by-environment interactions (GxE) is crucial to understand the interplay of environmental effects on complex traits. However, current methods evaluating GxE on biobank-scale datasets have limitations. We introduce MonsterLM, a multiple linear regression method that does not rely on model specification and provides unbiased estimates of variance explained by GxE. We demonstrate robustness of MonsterLM through comprehensive genome-wide simulations using real genetic data fro ...[more]