A pan-cancer analysis of potassium channel tetramerization domain containing 12 in human cancer.

ABSTRACT: Abnormal expression of the potassium channel tetramerization domain containing 12 (KCTD12) is closely related to the occurrence and development of various tumors, but a pan-cancer analysis of KCTD12 has not yet been conducted. We explored the association between KCTD12 and more than 30 human malignancies using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. First, the mRNA and protein levels of KCTD12 were examined and their correlations with tumor stage and survival were explored. Second, we analyzed the infiltration of CD8⁺ and CD4⁺ T cells and cancer-associated fibroblasts in tumors and explored the correlation between KCTD12 expression and tumor cell stemness, genomic heterogeneity, and diagnostic specificity. Finally, we explored the m

SUBMITTER: Liu P 

PROVIDER: S-EPMC10457314 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature