Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice.

ABSTRACT: Spaceflight-related stresses impact health via various body systems, including the haematopoietic and immune systems, with effects ranging from moderate alterations of homoeostasis to serious illness. Oxidative stress appears to be involved in these changes, and the transcription factor Nrf2, which regulates expression of a set of cytoprotective and antioxidative stress response genes, has been implicated in the response to spaceflight-induced stresses. Here, we show through analyses of mice from the MHU-3 project, in which Nrf2-knockout mice travelled in space for 31 days, that mice lacking Nrf2 suffer more seriously from spaceflight-induced immunosuppression than wild-type mice. We discovered that a one-month spaceflight-triggered the expression of tissue inflammatory marker genes in wil

SUBMITTER: Shimizu R 

PROVIDER: S-EPMC10457343 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature