Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease.

ABSTRACT: Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a complex risk structure thought to be influenced by interactions between genetic variants and environmental exposures, although the full aetiology is unknown. Environmental factors, including pesticides, have been reported to increase the risk of developing the disease. Growing evidence suggests epigenetic changes are key mechanisms by which these environmental factors act upon gene regulation, in disease-relevant cell types. We present a systematic review critically appraising and summarising the current body of evidence of the relationship between epigenetic mechanisms and environmental risk factors in PD to inform future research in this area. Epigenetic studies of relevant environmental risk factors in

SUBMITTER: Tsalenchuk M 

PROVIDER: S-EPMC10457362 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature