Using the TI.VA algorithm to titrate the depth of general anaesthesia: a first-in-humans study.

ABSTRACT:

Background

The dose of anaesthetic and opioid drugs must be continuously adjusted after the induction of general anaesthesia to maintain an adequate depth of anaesthesia. The TI.VA algorithm is a multiple-input/multiple-output algorithm designed to optimise the balance between anaesthetic and opioid concentrations during general anaesthesia. It applies vector analysis to a two-dimensional matrix to quantify any inadequacy of the depth of anaesthesia at any given moment and determine any drug dose adjustments required to achieve an adequate depth of anaesthesia. This study aimed to capture preliminary data on the performance and safety of the TI.VA algorithm during total i.v. anaesthesia in patients.

Methods

This prospective study enrolled nine patients with breast cancer sch

SUBMITTER: Tognoli E 

PROVIDER: S-EPMC10457467 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature