Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries.

ABSTRACT:

Background

This study assessed the potential cost-effectiveness of high (80-100%) vs low (21-35%) fraction of inspired oxygen (FiO₂) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa.

Methods

Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO₂, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($).

Results

High FiO₂ may be cost-effective (cheaper and effective). In Nigeria, the average

SUBMITTER: NIHR Global Health Research Unit on Global Surgery Collaborators 

PROVIDER: S-EPMC10457493 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature