Critical considerations in determining the surface charge of small extracellular vesicles.

ABSTRACT: Small extracellular vesicles (EVs) have emerged as a focal point of EV research due to their significant role in a wide range of physiological and pathological processes within living systems. However, uncertainties about the nature of these vesicles have added considerable complexity to the already difficult task of developing EV-based diagnostics and therapeutics. Whereas small EVs have been shown to be negatively charged, their surface charge has not yet been properly quantified. This gap in knowledge has made it challenging to fully understand the nature of these particles and the way they interact with one another, and with other biological structures like cells. Most published studies have evaluated EV charge by focusing on zeta potential calculated using classical theoretical approa

SUBMITTER: Tamrin SH 

PROVIDER: S-EPMC10457570 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature