Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases.

ABSTRACT:

Background

Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a μ-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in treating spinal metastasis pain.

Objective

To compare the efficacy of tapentadol and methadone with other opioids for back pain caused by a metastatic spinal tumor.

Design

Retrospective cohort study.

Setting/subjects

A total of 274 patients were enrolled, who started a tapentadol extended-release tablet, methadone tablet, hydromorphone extended-release tablet, oxycodone extended-release tablet, or transdermal fentanyl patch for cancer pain due to spinal metastasis in J

SUBMITTER: Takemura M 

PROVIDER: S-EPMC10457616 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature