Dataset Information

Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases.

ABSTRACT:

Background

Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a μ-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in treating spinal metastasis pain.

Objective

To compare the efficacy of tapentadol and methadone with other opioids for back pain caused by a metastatic spinal tumor.

Design

Retrospective cohort study.

Setting/subjects

A total of 274 patients were enrolled, who started a tapentadol extended-release tablet, methadone tablet, hydromorphone extended-release tablet, oxycodone extended-release tablet, or transdermal fentanyl patch for cancer pain due to spinal metastasis in Japan from January 1, 2013 to October 31, 2021.

Measurements

The primary endpoint, the difference in the numerical rating scale (NRS) scores before and seven days after each opioid administration, was compared among the five groups.

Results

In patients with numbness, a decrease of the NRS score on day seven compared with before starting each opioid was significantly higher in the tapentadol group than those in the hydromorphone, oxycodone, and fentanyl groups and comparable to that in the methadone group. In patients without numbness, no significant differences were observed in decreases of the NRS scores on day seven among the five groups.

Conclusions

Tapentadol and methadone may be more effective than hydromorphone, oxycodone, and fentanyl for cancer pain due to spinal metastasis with numbness.

SUBMITTER: Takemura M

PROVIDER: S-EPMC10457616 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases.

Takemura Miho M Niki Kazuyuki K Okamoto Yoshiaki Y Tamura Hiroshi H Kawamura Tomohiro T Kohno Makie M Matsuda Yoshinobu Y Ikeda Kenji K

Palliative medicine reports 20230809 1

<h4>Background</h4>Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a μ-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in treating spinal metastasis pain.<h4>Objective</h4>To compare the efficacy of tapentadol and methadone with other opioids for back pain caused by a metastatic spinal tumor.<h4>Design</h4>Retrospe ...[more]

PMID: 37637760

Similar Datasets

Project description:UnlabelledOpioids are regularly administered in acute and cancer pain. In chronic non-cancer pain (CNCP), however, their use is controversial. Previous meta-analyses and randomized controlled trials (RCTs) lack methodological homogeneity and comparable data. Here we analysed the maximum analgesic efficacies of opioids and non-opioids compared with placebo, and of physiotherapy and psychotherapy compared with active or waiting-list controls. We screened 3647 citations and included RCTs if treatment duration was at least 3 weeks, data were sufficient for meta-analysis, and criteria for high quality were met. Only 46 studies (10 742 patients) met the criteria. Weighted and standardized mean differences (WMD, SMD) between pain intensities were pooled to conduct separate meta-analyses for each treatment category. At the end of treatment the WMD for pain reduction (100-point scale) was 12.0 for 'strong' opioids, 10.6 for 'weak' opioids, 8.4 for non-opioids (each vs. placebo), 5.5 for psychotherapy and 4.5 for physiotherapy (each vs. active controls). Dropout rates were high in pharmacological studies. The 95% confidence intervals using the outcomes of control groups did not indicate statistical differences between efficacies of the five interventions. Because not enough eligible head-to-head trials were available, our analysis is limited to adjusted indirect comparisons. The heterogeneity of pre-post pain differences in control groups did not allow the definition of a common comparator. In conclusion, although there were statistically significant differences between maximum treatment efficacies, no intervention per se produced clinically important improvements in average pain intensity. Thus, opioids alone are inappropriate and multimodal treatment programmes may be required for CNCP.Linked articlesThis article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2.

Dataset Information

Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases.

Background

Objective

Design

Setting/subjects

Measurements

Results

Conclusions

Publications

Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases.

Similar Datasets

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