A Clonal Evolution Simulator for Planning Somatic Evolution Studies.

ABSTRACT: Somatic evolution plays a key role in development, cell differentiation, and normal aging, but also in diseases such as cancer. Understanding mechanisms of somatic mutability and how they can vary between cell lineages will likely play a crucial role in biological discovery and medical applications. This need has led to a proliferation of new technologies for profiling single-cell variation, each with distinctive capabilities and limitations that can be leveraged alone or in combination with other technologies. The enormous space of options for assaying somatic variation, however, presents unsolved informatics problems with regard to selecting optimal combinations of technologies for designing appropriate studies for any particular scientific questions. Versatile simulation tools are neede

SUBMITTER: Srivatsa A 

PROVIDER: S-EPMC10457648 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature