Gut Microbial and Associated Metabolite Markers for Colorectal Cancer Diagnosis

ABSTRACT: Globally, colorectal cancer (CRC) is the second most common cause of mortality worldwide. Considerable evidence indicates that dysbiosis of the gut microbial community and its metabolite secretions play a fundamental role in advanced adenoma (ADA) and CRC development and progression. This study is a systematic review that aims to assess the clinical association between gut microbial markers and/or gut and circulating metabolites with ADA and CRC. Five electronic databases were searched by four independent reviewers. Only controlled trials that compared ADA and/or CRC with healthy control (HC) using either untargeted (16s rRNA gene or whole genome sequencing) or targeted (gene-based real-time PCR) identification methods for gut microbiome profile, or untargeted or targeted metabolite profil

SUBMITTER: Alhhazmi A 

PROVIDER: S-EPMC10457972 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature