Photophysical Exploration of Alectinib and Rilpivirine: Insights from Theory and Experiment.

ABSTRACT: Due to the excellent characteristics of fluorescence-based imaging, such as non-invasive detection of biomarkers in vitro and in vivo with high sensitivity, good spatio-temporal resolution and fast response times, it has shown significant prospects in various applications. Compounds with both biological activities and fluorescent properties have the potential for integrated diagnosis and treatment application. Alectinib and Rilpivirine are two excellent drugs on sale that represent a clinically approved targeted therapy for ALK-rearranged NSCLC and have exhibited more favorable safety and tolerance profiles in Phase III clinical trials, ECHO and THRIVE, respectively. The optical properties of these two drugs, Alectinib and Rilpivirine, were deeply explored, firstly through the simulation o

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10458258 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature