Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players.

ABSTRACT: American-style football (ASF) players experience repetitive head impacts that may result in chronic traumatic encephalopathy neuropathological change (CTE-NC). At present, a definitive diagnosis of CTE-NC requires the identification of localized hyperphosphorylated Tau (p-Tau) after death via immunohistochemistry. Some studies suggest that positron emission tomography (PET) with the radiotracer [¹⁸F]-Flortaucipir (FTP) may be capable of detecting p-Tau and thus establishing a diagnosis of CTE-NC among living former ASF players. To assess associations between FTP, football exposure, and objective neuropsychological measures among former professional ASF players, we conducted a study that compared former professional ASF players with age-matched male control participants without r

SUBMITTER: Dhaynaut M 

PROVIDER: S-EPMC10458363 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature