Genome-Wide DNA Changes Acquired by Candida albicans Caspofungin-Adapted Mutants.

ABSTRACT: Drugs from the echinocandin (ECN) class are now recommended 'front-line' treatments of infections caused by a prevailing fungal pathogen, C. albicans. However, the increased use of ECNs is associated with a rising resistance to ECNs. As the acquisition of ECN resistance in C. albicans is viewed as a multistep evolution, determining factors that are associated with the decreased ECN susceptibility is of importance. We have recently identified two cohorts of genes that are either up- or downregulated in concert in order to control remodeling of cell wall, an organelle targeted by ECNs, in laboratory mutants with decreased ECN susceptibility. Here, we profiled the global DNA sequence of four of these adapted mutants in search of DNA changes that are associated with decreased ECN

SUBMITTER: Zuber J 

PROVIDER: S-EPMC10458384 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature