Gut Microbiota and Respiratory Infections: Insights from Mendelian Randomization.

ABSTRACT: The role of the gut microbiota in modulating the risk of respiratory infections has garnered increasing attention. However, conventional clinical trials have faced challenges in establishing the precise relationship between the two. In this study, we conducted a Mendelian randomization analysis with single nucleotide polymorphisms employed as instrumental variables to assess the causal links between the gut microbiota and respiratory infections. Two categories of bacteria, family Lactobacillaceae and genus Family XIII AD3011, were causally associated with the occurrence of upper respiratory tract infections (URTIs). Four categories of gut microbiota existed that were causally associated with lower respiratory tract infections (LRTIs), with order Bacillales and genus

SUBMITTER: Huang S 

PROVIDER: S-EPMC10458510 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature