Phenylalanine Tolerance over Time in Phenylketonuria: A Systematic Review and Meta-Analysis.

ABSTRACT: In phenylketonuria (PKU), natural protein tolerance is defined as the maximum natural protein intake maintaining a blood phenylalanine (Phe) concentration within a target therapeutic range. Tolerance is affected by several factors, and it may differ throughout a person's lifespan. Data on lifelong Phe/natural protein tolerance are limited and mostly reported in studies with low subject numbers. This systematic review aimed to investigate how Phe/natural protein tolerance changes from birth to adulthood in well-controlled patients with PKU on a Phe-restricted diet. Five electronic databases were searched for articles published until July 2020. From a total of 1334 results, 37 articles met the eligibility criteria (n = 2464 patients), and 18 were included in the meta-analysis. The mea

SUBMITTER: Pinto A 

PROVIDER: S-EPMC10458574 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature