Comparative Analysis of Prokaryotic Extracellular Vesicle Proteins and Their Targeting Signals.

ABSTRACT: Prokaryotic extracellular vesicles (EVs) are vesicles that bud from the cell membrane and are secreted by bacteria and archaea. EV cargo in Gram-negative bacteria includes mostly periplasmic and outer membrane proteins. EVs are clinically important as their cargo can include toxins associated with bacterial virulence and toxicity; additionally, they have been proposed as efficient vaccine agents and as the ancestors of the eukaryotic endomembrane system. However, the mechanistic details behind EV cargo selection and release are still poorly understood. In this study, we have performed bioinformatics analysis of published data on EV proteomes from 38 species of bacteria and 4 archaea. Focusing on clusters of orthologous genes (COGs) and using the EggNOG mapper function, we have identified c

SUBMITTER: Stathatos I 

PROVIDER: S-EPMC10458587 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature