Current Advances in Humanized Mouse Models for Studying NK Cells and HIV Infection.

ABSTRACT: Human immunodeficiency virus (HIV) has infected millions of people worldwide and continues to be a major global health problem. Scientists required a small animal model to study HIV pathogenesis and immune responses. To this end, humanized mice were created by transplanting human cells and/or tissues into immunodeficient mice to reconstitute a human immune system. Thus, humanized mice have become a critical animal model for HIV researchers, but with some limitations. Current conventional humanized mice are prone to death by graft versus host disease induced by the mouse signal regulatory protein α and CD47 signaling pathway. In addition, commonly used humanized mice generate low levels of human cytokines required for robust myeloid and natural killer cell development and function. Here, we

SUBMITTER: Kim JT 

PROVIDER: S-EPMC10458594 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature