Ontology highlight
ABSTRACT:
SUBMITTER: Park Y
PROVIDER: S-EPMC10458605 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Park Yukyung Y Srigouri Huddar H Kim Dongwon D
Molecules (Basel, Switzerland) 20230818 16
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by pruritic lesions and skin barrier dysfunction. In this study, we evaluated the effect of a quinazoline derivative, SH-340, on TSLP expression and signaling in human primary keratinocytes. Our results demonstrated that SH-340 significantly increased factors for differentiation and skin barrier function including KRT1, KRT2, KRT10, IVL, LOR, CLDN1, OVOL1, and FLG, whereas it inhibited TSLP expression in a dose-dependent ...[more]