Pluronic F-68 and F-127 Based Nanomedicines for Advancing Combination Cancer Therapy.

ABSTRACT: Pluronics are amphiphilic triblock copolymers composed of two hydrophilic poly (ethylene oxide) (PEO) chains linked via a central hydrophobic polypropylene oxide (PPO). Owing to their low molecular weight polymer and greater number of PEO segments, Pluronics induce micelle formation and gelation at critical micelle concentrations and temperatures. Pluronics F-68 and F-127 are the only United States (U.S.) FDA-approved classes of Pluronics and have been extensively used as materials for living bodies. Owing to the fascinating characteristics of Pluronics, many studies have suggested their role in biomedical applications, such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. As a result, various studies have been performed using Pluronics as a tool in nanomedici

SUBMITTER: Khaliq NU 

PROVIDER: S-EPMC10458801 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature