Targeting EGFR/PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) poses a significant global health concern, with its incidence steadily increasing. The development of HCC is a multifaceted, multi-step process involving alterations in various signaling cascades. In recent years, significant progress has been made in understanding the molecular signaling pathways that play central roles in hepatocarcinogenesis. In particular, the EGFR/PI3K/AKT/mTOR signaling pathway in HCC has garnered renewed attention from both basic and clinical researchers. Preclinical studies in vitro and in vivo have shown the effectiveness of targeting the key components of this signaling pathway in human HCC cells. Thus, targeting these signaling pathways with small molecule inhibitors holds promise as a potential therapeutic option for patients with

SUBMITTER: Bang J 

PROVIDER: S-EPMC10458925 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature