Comprehensive analysis for the immune related biomarkers of platinum-based chemotherapy in ovarian cancer

ABSTRACT:

Background

Ovarian cancer (OC) is one of the most lethal gynecological malignancies. This study aimed to identify biomarkers that were sensitive to platinum-based chemotherapeutic agents and can be used in immunotherapy and explore the importance of their mechanisms of action.

Methods

RNA-seq profiles and clinicopathological data for OC samples were obtained from The Cancer Genome Atlas (TCGA) and cBioPortal platform, respectively. Platinum-sensitive and platinum-resistant OC samples in the TCGA cohort were selected based on the clinical information. RNA-seq data for 70 OC samples withSingle-sample gene set enrichment analysis (ssGSEA) and unsupervised clustering were used to classify OC patients from the TCGA cohort into clusters with different proportions of infiltratin

SUBMITTER: Liu J 

PROVIDER: S-EPMC10458992 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature