Stability of Monoclonal Antibodies as Solid Formulation for Auto-Injectors: A Pilot Study.

ABSTRACT: Drug adherence is a significant medical issue, often responsible for sub-optimal outcomes during the treatment of chronic diseases such as rheumatoid or psoriatic arthritis. Monoclonal antibodies (which are exclusively given parenterally) have been proven to be an effective treatment in these cases. The use of auto-injectors is an effective strategy to improve drug adherence in parenteral treatments since these pen-like devices offer less discomfort and increased user-friendliness over conventional syringe-based delivery. This study aims to investigate the feasibility of including a monoclonal antibody as a solid formulation inside an auto-injector pen. Specifically, the objective was to evaluate the drug stability after a concentration (to reduce the amount of solvent and space needed) an

SUBMITTER: Garcia-Villen F 

PROVIDER: S-EPMC10459033 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature