Anticholinesterase and Serotoninergic Evaluation of Benzimidazole-Carboxamides as Potential Multifunctional Agents for the Treatment of Alzheimer's Disease.

ABSTRACT: The etiology and pathogenesis of Alzheimer's disease are multifactorial, so one of the treatment strategies is the development of the drugs that affect several targets associated with the pathogenesis of the disease. Within this roadmap, we investigated the interaction of several substituted 1,3-dihydro-2-oxo-1H-benzimidazol-2-ones with their potential molecular targets: cholinesterases (ChE) and three types of the G_s-protein-coupled serotonin receptors (5-HTR) 5-HT₆, 5-HT₄ and 5-HT₇ (5-HT₄R, 5-HT₆R and 5-HT₇R, respectively). A microplate modification of the Ellman method was used for the biochemical analysis of the inhibitory ability of the drugs towards ChE. Molecular modeling methods, such as molecular d

SUBMITTER: Belinskaia DA 

PROVIDER: S-EPMC10459044 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature