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The Hepatitis B Virus Genotypes E to J: The Overlooked Genotypes.


ABSTRACT: Hepatitis B virus (HBV) genotypes E to J are understudied genotypes. Genotype E is found almost exclusively in West Africa. Genotypes F and H are found in America and are rare in other parts of the world. The distribution of genotype G is not completely known. Genotypes I and J are found in Asia and probably result from recombination events with other genotypes. The number of reported sequences for HBV genotypes E to J is small compared to other genotypes, which could impact phylogenetic and pairwise distance analyses. Genotype F is the most divergent of the HBV genotypes and is subdivided into six subgenotypes F1 to F6. Genotype E may be a recent genotype circulating almost exclusively in sub-Saharan Africa. Genotype J is a putative genotype originating from a single Japanese patient. The paucity of data from sub-Saharan Africa and Latin America is due to the under-representation of these regions in clinical and research cohorts. The purpose of this review is to highlight the need for further research on HBV genotypes E to J, which appear to be overlooked genotypes.

SUBMITTER: Toye RM 

PROVIDER: S-EPMC10459053 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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The Hepatitis B Virus Genotypes E to J: The Overlooked Genotypes.

Toyé Rayana Maryse RM   Loureiro Carmen Luisa CL   Jaspe Rossana Celeste RC   Zoulim Fabien F   Pujol Flor Helene FH   Chemin Isabelle I  

Microorganisms 20230727 8


Hepatitis B virus (HBV) genotypes E to J are understudied genotypes. Genotype E is found almost exclusively in West Africa. Genotypes F and H are found in America and are rare in other parts of the world. The distribution of genotype G is not completely known. Genotypes I and J are found in Asia and probably result from recombination events with other genotypes. The number of reported sequences for HBV genotypes E to J is small compared to other genotypes, which could impact phylogenetic and pai  ...[more]

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