Carvacrol Inhibits Quorum Sensing in Opportunistic Bacterium Aeromonas hydrophila.

ABSTRACT: Bacterial quorum sensing (QS) plays a crucial role in chemical communication between bacteria involving autoinducers and receptors and controls the production of virulence factors in bacteria. Therefore, reducing the concentration of signaling molecules in QS is an effective strategy for mitigating the virulence of pathogenic bacteria. In this study, we demonstrated that carvacrol at 15.625 μg/mL (1/4 MIC), a natural compound found in plants, exhibits potent inhibitory activity against QS in Chromobacterium violaceum, as evidenced by a significant reduction (62.46%) in violacein production. Based on its impressive performance, carvacrol was employed as a natural QS inhibitor to suppress the pathogenicity of Aeromonas hydrophila NJ-35. This study revealed a significant reducti

SUBMITTER: Lu L 

PROVIDER: S-EPMC10459158 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature