Cytotoxicity Analysis and In Silico Studies of Three Plant Extracts with Potential Application in Treatment of Endothelial Dysfunction.

ABSTRACT: Endothelial dysfunction is the basis of the physiopathological mechanisms of vascular diseases. In addition to the therapeutic activity of plant extracts, cytotoxicity is significant. This research evaluates the cytotoxicity of three vegetal extracts (Calendulae flos extract-CE, Ginkgo bilobae folium extract-GE, and Sophorae flos extract-SE). In vitro evaluation was performed using an endothelial cell line model (Human Pulmonary Artery Endothelial Cells-HPAEC) when a dose-dependent cytotoxic activity was observed after 72 h. The IC₅₀ values were calculated for all extracts: Calendulae flos extract (IC₅₀ = 91.36 μg/mL), Sophorae flos extract (IC₅₀ = 68.61 μg/mL), and Ginkgo bilobae folium extract (IC₅₀ = 1

SUBMITTER: Ungureanu AR 

PROVIDER: S-EPMC10459174 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature