Dipeptidyl Peptidase IV Inhibitory Peptides from Chickpea Proteins (Cicer arietinum L.): Pharmacokinetics, Molecular Interactions, and Multi-Bioactivities.

ABSTRACT: Chickpea (Cicer arietinum L.) peptides can inhibit dipeptidyl peptidase IV (DPP-IV), an important type 2 diabetes mellitus therapeutic target. The molecular interactions between the inhibitory peptides and the active site of DPP-IV have not been thoroughly examined, nor have their pharmacokinetic properties. Therefore, the predictions of legumin- and provicilin-derived DPP-IV inhibitory peptides, their molecular interactions with the active site of DPP-IV, and their pharmacokinetic properties were carried out. Ninety-two unique DPP-IV inhibitory peptides were identified. Papain and trypsin were the enzymes with the highest A_E (0.0927) and lowest B_E (6.8625 × 10^-7) values, respectively. Peptide binding energy values ranged from -5.2 to -7.9 kcal/mol.

SUBMITTER: Mora-Melgem JA 

PROVIDER: S-EPMC10459228 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature