Polymeric Delivery Systems as a Potential Vaccine against Visceral Leishmaniasis: Formulation Development and Immunogenicity.

ABSTRACT: Recent studies suggest that the association of antigens in microparticles increases the anti-Leishmania vaccine immunogenicity. This study aims to investigate the in situ effect of the adjuvant performance consisting of chitosan-coated poly(D,L-lactic) acid submicrometric particles (SMP) and analyze the inflammatory profile and toxicity. Two formulations were selected, SMP¹, containing poly(D,L-lactide) (PLA) 1% wt/v and chitosan 1% wt/v; and SMP², containing PLA 5% wt/v and chitosan 5% wt/v. After a single dose of the unloaded SMP¹ or SMP² in mice, the SMPs promoted cell recruitment without tissue damage. In addition, besides the myeloperoxidase (MPO) acti

SUBMITTER: Silva JGLD 

PROVIDER: S-EPMC10459565 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature