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Chitosan and Its Carboxymethyl-Based Membranes Produced by Crosslinking with Magnesium Phytate.

ABSTRACT: Membranes produced by crosslinking chitosan with magnesium phytate were prepared using highly deacetylated chitosan and its N-carboxymethyl, O-carboxymethyl and N,O-carboxymethyl derivatives. The conditions of the membrane production were described. IR, Raman, electron absorption and emission spectra were measured and analyzed for all the substrates. It was found that O-carboxymethyl chitosan derivative is the most effectively crosslinked by magnesium phytate, and the films formed on this substrate exhibit good mechanical parameters of strength, resistance and stability. Strong O-H···O hydrogen bonds proved to be responsible for an effective crosslinking process. Newly discovered membrane types produced from chitosan and magnesium phytate were characterized as morphologically homogenous and uniform by scanning electron microscopy (SEM) and IR measurements. Due to their good covering properties, they do not have pores or channels and are proposed as packaging materials.

SUBMITTER: Zajac A

PROVIDER: S-EPMC10459599 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Chitosan and Its Carboxymethyl-Based Membranes Produced by Crosslinking with Magnesium Phytate.

Zając Adam A Sąsiadek Wojciech W Dymińska Lucyna L Ropuszyńska-Robak Paulina P Hanuza Jerzy J Ptak Maciej M Smółka Szymon S Lisiecki Radosław R Skrzypczak Katarzyna K

Molecules (Basel, Switzerland) 20230810 16

Membranes produced by crosslinking chitosan with magnesium phytate were prepared using highly deacetylated chitosan and its N-carboxymethyl, O-carboxymethyl and N,O-carboxymethyl derivatives. The conditions of the membrane production were described. IR, Raman, electron absorption and emission spectra were measured and analyzed for all the substrates. It was found that O-carboxymethyl chitosan derivative is the most effectively crosslinked by magnesium phytate, ...[more]

PMID: 37630242

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Project description:There is a continuing need for artificial bone substitutes for bone repair and reconstruction, Magnesium phosphate bone cement (MPC) has exceptional degradable properties and exhibits promising biocompatibility. However, its mechanical strength needs improved and its low osteo-inductive potential limits its therapeutic application in bone regeneration. We functionally modified MPC by using a polymeric carboxymethyl chitosan-sodium alginate (CMCS/SA) gel network. This had the advantages of: improved compressive strength, ease of handling, and an optimized interface for bioactive bone in-growth. The new composites with 2% CMCS/SA showed the most favorable physicochemical properties, including mechanical strength, wash-out resistance, setting time, injectable time and heat release. Biologically, the composite promoted the attachment and proliferation of osteoblast cells. It was also found to induce osteogenic differentiation in vitro, as verified by expression of osteogenic markers. In terms of molecular mechanisms, data showed that new bone cement activated the Wnt pathway through inhibition of the phosphorylation of β-catenin, which is dependent on focal adhesion kinase. Through micro-computed tomography and histological analysis, we found that the MPC-CMCS/SA scaffolds, compared with MPC alone, showed increased bone regeneration in a rat calvarial defect model. Overall, our study suggested that the novel composite had potential to help repair critical bone defects in clinical practice. Graphical abstract Image 1 Highlights • CMCS/SA improves the mechanical strength of MPC while minimizing tissue damage.• The MPC-CMCS/SA composite is easily manipulable for clinical application.• MPC-CMCS/SA has good biocompatibility, and is easier for cell adhesion and proliferation.• The MPC-CMCS/SA composite enhances osteogenic differentiation in vitro through the integrin-FAK-Wnt axis.• The MPC-CMCS/SA composite enhances critical bone defect repair in vivo.

Dataset Information

Chitosan and Its Carboxymethyl-Based Membranes Produced by Crosslinking with Magnesium Phytate.

Publications

Chitosan and Its Carboxymethyl-Based Membranes Produced by Crosslinking with Magnesium Phytate.

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