Vinylation of N-Heteroarenes through Addition/Elimination Reactions of Vinyl Selenones.

ABSTRACT: A new protocol for the synthesis of N-vinyl azoles using vinyl selenones and azoles in the presence of potassium hydroxide was developed. This reaction proceeded under mild and transition metal-free conditions through an addition/elimination cascade process. Both aromatic and aliphatic vinyl selenones and various mono-, bi- and tri-cyclic azoles can be tolerated and give terminal N-vinyl azoles in moderate to high yields. A plausible mechanism is also proposed.

SUBMITTER: Palomba M 

PROVIDER: S-EPMC10459632 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature