Yeast Deletomics to Uncover Gadolinium Toxicity Targets and Resistance Mechanisms.

ABSTRACT: Among the rare earth elements (REEs), a crucial group of metals for high-technologies. Gadolinium (Gd) is the only REE intentionally injected to human patients. The use of Gd-based contrasting agents for magnetic resonance imaging (MRI) is the primary route for Gd direct exposure and accumulation in humans. Consequently, aquatic environments are increasingly exposed to Gd due to its excretion through the urinary tract of patients following an MRI examination. The increasing number of reports mentioning Gd toxicity, notably originating from medical applications of Gd, necessitates an improved risk-benefit assessment of Gd utilizations. To go beyond toxicological studies, unravelling the mechanistic impact of Gd on humans and the ecosystem requires the use of genome-wide approaches. We used

SUBMITTER: Grosjean N 

PROVIDER: S-EPMC10459663 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature