Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy.

ABSTRACT: We evaluated the pharmaceutical properties of levofloxacin (LV) in the form of an orally disintegrating tablet (LV_ODT) to find a new usefulness of low frequency (LF) Raman spectroscopy. LV_ODT contained dispersed granules with diameters in the order of several hundred micrometers, which were composed of the active pharmaceutical ingredient (API), as confirmed by infrared (IR) microspectroscopy. On the contrary, the API and inactive pharmaceutical ingredients (non-APIs) were homogeneously distributed in LV tablet (LV_T) formulations. Microscopic IR spectroscopy and thermal analyses showed that LV_ODT and LV_T contained the API in different crystalline forms or environment around the API each other. Further

SUBMITTER: Yamamoto Y 

PROVIDER: S-EPMC10459943 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature