Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole.

ABSTRACT: Surfactants have been widely used as effective additives to increase the solubility and dissolution rates of amorphous solid dispersions (ASDs). However, they may also generate adverse effects on the physical stability of ASDs. In this study, we systematically investigated the impacts of poloxamer, a frequently used surfactant, on the crystallization of amorphous clotrimazole (CMZ). The added poloxamer significantly decreased the glass transition temperature (Tg) of CMZ and accelerated the growth of Form 1 and Form 2 crystals. It was found that the poloxamer had an accelerating effect on Form 1 and Form 2 but showed a larger accelerating effect on Form 1, which resulted from a combined effect of increased mobility and local phase separation at the crystal-liquid interface. Additiona

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10460058 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature