Smartphone-based dual radiometric fluorescence and white-light imager for quantification of protoporphyrin IX in skin.

ABSTRACT:

Significance

The quantification of protoporphyrin IX (PpIX) in skin can be used to study photodynamic therapy (PDT) treatments, understand porphyrin mechanisms, and enhance preoperative mapping of non-melanoma skin cancers.

Aim

We aim to develop a smartphone-based imager for performing simultaneous radiometric fluorescence (FL) and white light (WL) imaging to study the baseline levels, accumulation, and photobleaching of PpIX in skin.

Approach

A smartphone-based dual FL and WL imager (sDUO) is introduced alongside new radiometric calibration methods for providing SI-units of measurements in both pre-clinical and clinical settings. These radiometric measurements and corresponding PpIX concentration estimations are applied to clinical measurements to understand mechanis

SUBMITTER: Ruiz AJ 

PROVIDER: S-EPMC10460113 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature