Platelet transfusions in preterm infants: current concepts and controversies-a systematic review and meta-analysis.

ABSTRACT: Platelet transfusions (PTx) are the principal approach for treating neonatal thrombocytopenia, a common hematological abnormality affecting neonates, particularly preterm infants. However, evidence about the outcomes associated with PTx and whether they provide clinical benefit or harm is lacking. The aim of this systematic review and meta-analysis is to assess the association between PTx in preterm infants and mortality, major bleeding, sepsis, and necrotizing enterocolitis (NEC) in comparison to not transfusing or using different platelet count thresholds for transfusion. A broad electronic search in three databases was performed in December 2022. We included randomized controlled trials, and cohort and case control studies of preterm infants with thrombocytopenia that (i) compared treat

SUBMITTER: Ribeiro HS 

PROVIDER: S-EPMC10460362 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature